Key result
This systematic review aimed to summarize cases of digoxin toxicity, risk factors, and drug-drug interactions in patients with atrial fibrillation and congestive heart failure.
Why the study?
Digoxin use is limited by a narrow therapeutic index and risk of toxicity, prompting a summary of digoxin toxicity cases, risk factors, and drug-drug interactions.
What are the features, risk factors, and drug-drug interactions associated with digoxin toxicity in patients with atrial fibrillation and congestive heart failure?
Systematic Review
What are the features, risk factors, and drug-drug interactions associated with digoxin toxicity in patients with atrial fibrillation and congestive heart failure?
This systematic review summarizes the clinical features, risk factors, and drug interactions associated with digoxin toxicity in patients with heart failure and atrial fibrillation.
Clinicians should heighten monitoring in elderly females with renal impairment or diuretic use; supports known toxicity features from limited case reports.
Digoxin is a cardiac glycoside indicated for the treatment of congestive heart failure, atrial fibrillation or flutter, and certain cardiac arrhythmias. The use of digoxin is limited due to its narrow therapeutic index nature. In high concentrations, digoxin has been associated with toxicity features such as gastrointestinal symptoms, visual effects, and cardiac arrhythmia. This systematic review aims to summarize cases of digoxin toxicity including the risk factors, possible drug-drug interacti
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Redzuan et al. (2023) conducted a systematic review in Atrial fibrillation and congestive heart failure. Digoxin was evaluated on Cases of digoxin toxicity, risk factors, and drug-drug interactions. This systematic review aimed to summarize cases of digoxin toxicity, risk factors, and drug-drug interactions in patients with atrial fibrillation and congestive heart failure.
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