Key result
Digoxin use induces characteristic ECG changes and triggers potentially lethal arrhythmias in toxicity.
Why the study?
Despite widespread use of digoxin in heart failure and atrial fibrillation, clinicians have limited experience recognizing signs of potentially lethal digoxin toxicity.
Case Report (n=2)
Highlights the importance of recognizing clinical signs and electrocardiographic changes associated with potentially lethal digoxin toxicity.
Raises awareness of digoxin toxicity ECG changes among clinicians; leaves open prospective evaluation of diagnostic and treatment approaches.
Digoxin is a commonly prescribed drug in the management of heart failure and atrial fibrillation. Despite its widespread use, most clinicians have little experience with recognising clinical signs and symptoms that might suggest a potentially lethal drug toxicity. We herein describe two cases with specific reference to the electrocardiographic changes induced by digoxin and discuss the predisposing factors for toxicity, recognition of possible toxicity and treatment approaches.
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Djohan et al. (2020) conducted a case report in Digoxin toxicity and electrocardiographic changes (n=2). Digoxin was evaluated. Digoxin use is associated with characteristic electrocardiographic changes at therapeutic levels and can cause potentially lethal arrhythmias during toxicity, requiring prompt recognition.
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