Key result
Selective norepinephrine reuptake inhibition with reboxetine significantly increased heart rate during a 75-degree head-up tilt test compared to placebo (119 vs 84 bpm; P<0.0001).
Why the study?
Does reboxetine alter cardiovascular responses to orthostatic stress and autonomic testing in healthy subjects?
Population
18 healthy subjects
Comparison
Reboxetine 8 mg ingested 12 hours and 1 hour… vs Placebo ingested 12 hours and 1 hour before…
Design
RCT, randomized, crossover fashion, double-blind
Authors
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Reboxetine induces orthostatic intolerance-like responses while attenuating vasovagal reactions; extends mechanistic understanding of NET inhibition in autonomic regulation.
RCT (n=18)
double-blind
randomized crossover
Does reboxetine alter cardiovascular responses to orthostatic stress and autonomic testing in healthy subjects?
Absolute Event Rate: 119% vs 84%
p-value: p=<0.0001
Selective norepinephrine transporter blockade with reboxetine induces a phenotype resembling idiopathic orthostatic intolerance and reduces vasovagal reactions during tilt testing.
Schroeder et al. (2002) conducted an RCT in healthy subjects (n=18). reboxetine vs. placebo was evaluated on heart rate at 75 degrees head-up tilt test (HUT) (p=<0.0001). Selective norepinephrine reuptake inhibition with reboxetine significantly increased heart rate during a 75-degree head-up tilt test compared to placebo (119 vs 84 bpm; P<0.0001).
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