Why the study?
Does CO2 rebreathing improve cerebral hypoperfusion and symptoms in patients with orthostatic intolerance during head-up tilt?
Population
30 patients with orthostatic intolerance and 17 control subjects.
Comparison
Head-up tilt with hyperventilation and CO2… vs Supine rest and spontaneous breathing
Design
Cross-sectional
Authors
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CO2 rebreathing may rapidly reverse hypoperfusion in OI during tilt; hypothesis-generating, requires randomized trials before practice change.
Does CO2 rebreathing improve cerebral hypoperfusion and symptoms in patients with orthostatic intolerance during head-up tilt?
Cerebral hypoperfusion in orthostatic intolerance is largely due to hyperventilation-induced hypocapnia and can be rapidly reversed with CO2 rebreathing.
Novak et al. (1998) studied this question.
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