Why the study?
Do volume loading, phenylephrine, or phentolamine attenuate the decrease in cerebral blood flow during head-up tilt in patients with idiopathic orthostatic intolerance?
Population
9 patients (8 women and 1 man aged 22 to 48 years) with idiopathic orthostatic intolerance (IOI)
Comparison
Volume loading, alpha-adrenoreceptor agonism… vs Placebo
Design
Other
Authors
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Volume loading or alpha blockade may preserve cerebral perfusion in orthostatic intolerance; hypothesis-generating and requires confirmation in larger trials.
Do volume loading, phenylephrine, or phentolamine attenuate the decrease in cerebral blood flow during head-up tilt in patients with idiopathic orthostatic intolerance?
In patients with idiopathic orthostatic intolerance, interventions that improve systemic hemodynamics or block alpha-adrenoreceptors attenuate the paradoxical decrease in cerebral blood flow during upright posture.
Jordan et al. (1998) studied this question.
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