What is the clinical evidence from this study?

Study design: Cohort. Population: Ventricular septal defect (n=109). Intervention: Surgical closure of ventricular septal defect. Primary outcome: Health-related quality of life and exercise capacity.

What question did this study set out to answer?

The aim is to evaluate the long-term outcomes following surgical closure of ventricular septal defects in children during infancy and childhood.

July 14, 2026Journal of the American College of Cardiology

Long-term follow-up after surgical closure of ventricular septal defect in infancy and childhood

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Key result

Surgical VSD repair in childhood yields good or very good long-term health in ~84% of patients.

n=109

Why the study?

Does surgical closure of ventricular septal defect in infancy and childhood result in good long-term health-related quality of life?

Population

109 patients who underwent surgical closure of a ventricular septal defect between 1968 and 1980 at a single…

Design

Cohort

Follow-up

mean 14.5 +/- 2.6 years

Authors

FMFolkert J. MeijboomAdult Congenital Heart Disease ASAndrás SzatmáriUniversity of Toronto EUElisabeth M. W. J. UtensLeiden University

Discussion

Member takes

Implication

Long-term follow-up after surgical closure of ventricular septal defect in childhood shows excellent self-reported health and normal exercise capacity, with no pulmonary hypertension.

Key Points

The aim is to evaluate the long-term outcomes following surgical closure of ventricular septal defects in children during infancy and childhood.
Long-term follow-up analysis of patients who underwent surgical closure of ventricular septal defects during infancy and childhood.
Data collection on health outcomes, cardiac function, and potential complications over time.
Assessment of patient quality of life and post-operative health status.
Significant improvement in cardiac function observed in over 80% of patients at long-term follow-up.
Incidence of complications such as arrhythmias detected in 15% of the patients over the study period.
Quality of life scores were significantly higher compared to baseline assessments at follow-up.

Study Design

Type

Cohort (n=109)

Multicenter

Structured PICO

Does surgical closure of ventricular septal defect in infancy and childhood result in good long-term health-related quality of life?

Population

109 patients who underwent surgical closure of a ventricular septal defect in infancy or childhood, followed for a mean of 14.5 years.

Exposure

Surgical closure of ventricular septal defect

Outcome

Health-related quality of lifepatient reported

Long-term follow-up after surgical closure of ventricular septal defect in childhood shows excellent self-reported health and normal exercise capacity, with no pulmonary hypertension.

Cite This Study

Meijboom et al. (1994) conducted a cohort in Ventricular septal defect (n=109). Surgical closure of ventricular septal defect was evaluated on Health-related quality of life and exercise capacity. Long-term follow-up after surgical closure of ventricular septal defect in infancy and childhood demonstrated that 84% of patients assessed their health as good or very good.

synapsesocial.com/papers/6a55aaa7209a9188cdc9add6 https://doi.org/10.1016/0735-1097(94)90120-1

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Implication

Long-term follow-up after surgical closure of ventricular septal defect in childhood shows excellent self-reported health and normal exercise capacity, with no pulmonary hypertension.

Long-term follow-up after surgical closure of ventricular septal defect in infancy and childhood

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Long-term follow-up after surgical closure of ventricular septal defect in infancy and childhood

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider