What does this research mean for the field?

The novel PSMA-targeted ratiometric near-infrared fluorescent probe, PSMA-ratio-pH, enables rapid, real-time, and precise noninvasive imaging of extracellular acidity in prostate cancer. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to develop a highly sensitive ratiometric near-infrared fluorescent probe for imaging acidic environments in prostate cancer.

July 14, 2026Chemistry - A European Journal

A Highly Sensitive PSMA‐Targeted Ratiometric NIR Probe for Rapid Imaging of Prostate Cancer Acidity in Living Mice

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Authors

XCXuekang CaiPeking University JZJingming ZhangEli Lilly (United States)WHW Q HuangJinan University

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Implication

Randomized trial demonstrates rapid imaging of prostate cancer acidity in mice, highlighting its diagnostic potential.

Key Points

This research aims to develop a highly sensitive ratiometric near-infrared fluorescent probe for imaging acidic environments in prostate cancer.
Developed a small-molecule probe PSMA-ratio-pH targeting prostate-specific membrane antigen (PSMA).
Conducted cellular experiments to confirm probe selectivity and binding.
Utilized mouse models of prostate cancer to assess probe performance in imaging pH changes.
The probe enabled rapid tumor targeting and imaging of acidity within 15 minutes post-intravenous injection.
Achieved a pKa of 6.4, suitable for detecting tumor acidity changes and demonstrated 1250-fold activation sensitivity.
Proved capable of reliably monitoring dynamic pH changes in the tumor microenvironment.

Cite This Study

Cai et al. (2026) studied this question.

synapsesocial.com/papers/6a55d16e5aafca87247f8721 https://doi.org/10.1002/chem.71411

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A Highly Sensitive PSMA‐Targeted Ratiometric NIR Probe for Rapid Imaging of Prostate Cancer Acidity in Living Mice

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Cite This Study

A Highly Sensitive PSMA‐Targeted Ratiometric NIR Probe for Rapid Imaging of Prostate Cancer Acidity in Living Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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