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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Imaging tumor extracellular pH using PET/MRI co-agents

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Authors

CDChetan DhakanUniversity of Wisconsin–Madison XLXiaofei LiangResearch Institute of Petroleum Exploration and Development LPLorenzo Palagi

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Implication

Evaluation reveals accurate tumor pHe measurement in a mouse model, indicating potential for cancer diagnosis. This dual approach enhances treatment response monitoring, transforming care strategies.

Key Points

The dual PET/MRI approach accurately measures tumor pHe, leading to improved detection of treatment response.
Using 68Ga and 18F based agents, the method achieved high precision in determining tumor pHe values in mouse models.
The results from the 18F co-agents closely aligned with gold-standard pH sensors, validating their accuracy in this setting.
This non-invasive technique could significantly enhance personalized cancer therapy strategies by enabling earlier assessments.

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Dhakan et al. (2025) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c79b https://doi.org/10.58530/2025/1149

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Implication

Evaluation reveals accurate tumor pHe measurement in a mouse model, indicating potential for cancer diagnosis. This dual approach enhances treatment response monitoring, transforming care strategies.

Imaging tumor extracellular pH using PET/MRI co-agents

Discussion

Member takes

Implication

Key Points

Cite This Study

Imaging tumor extracellular pH using PET/MRI co-agents

Discussion

Member takes

Implication

Key Points

Cite This Study

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