Key result
Intradialytic hypotension is linked to a ~7% post-dialysis reduction in RVFWS.
Why the study?
Intradialytic hypotension is a frequent hemodialysis complication linked to adverse cardiovascular consequences, but the contribution of RV functional reserve to hemodynamic stability during dialysis remains unclear.
Does dynamic change in right ventricular free wall strain during hemodialysis predict intradialytic hypotension in patients with end-stage renal disease?
Observational (n=33)
Single-blind (offline strain analysis)
No
Does dynamic change in right ventricular free wall strain during hemodialysis predict intradialytic hypotension in patients with end-stage renal disease?
Dynamic assessment of right ventricular free wall strain during hemodialysis can help identify patients with impaired right ventricular contractile reserve who are at risk for intradialytic hypotension.
Answers are grounded in this paper and cite their sources.
Intradialytic hypotension was associated with greater right ventricular strain reduction; hypothesis-generating and requires prospective validation before clinical adoption.
Background: Intradialytic hypotension (IDH) is a frequent complication of hemodialysis that is associated with adverse cardiovascular consequences.The contribution of right ventricular (RV) functional reserve to hemodynamic stability during dialysis remains unclear.We investigated whether dynamic changes in RV strain are associated with IDH.Methods: In this prospective single-center study, 50 patients with end-stage renal disease undergoing maintenance hemodialysis underwent comprehensive echocardiography with speckle-tracking analysis immediately before and after dialysis.IDH was defined as a decrease in systolic blood pressure (SBP) of ≥ 20 mmHg from pre-to post-dialysis.Right ventricular free wall strain (RVFWS) was analyzed offline by a blinded specialist.Changes in RVFWS were compared between patients with and without IDH, and correlations between SBP change and RVFWS change were assessed.Results: In the analyzed 33 patients, 15 patients (45%) developed IDH.Baseline clinical characteristics, ultrafiltration volume (mean, 2.9 L), and pre-dialysis SBP were comparable between groups.Left ventricular ejection fraction was preserved in most patients, and baseline RVFWS did not differ significantly.However, the IDH group showed a significantly greater post-dialysis reduction in RVFWS than the non-IDH group (-7.0 ± 7.2% vs. -1.7 ± 4.6%, P = 0.017).Moreover, the magnitude of SBP decline correlated moderately with the decrease in RVFWS (r = 0.50, P = 0.003).Receiver operating characteristic analysis suggested a modest discriminatory ability of dialysis-induced changes in RVFWS for IDH (area under the curve, 0.74; 95% confidence interval, 0.56-0.92).Conclusions: IDH was associated with a greater dialysis-induced decline in RVFWS despite similar baseline RV function, suggesting that acute volume unloading may unmask impaired RV contractile reserve.These findings provide preliminary evidence that dynamic RV strain assessment could help identify patients vulnerable to intradialytic hemodynamic instability, warranting further validation in larger studies.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2026) conducted an observational in End-stage renal disease (n=33). Intradialytic hypotension (IDH) vs. No intradialytic hypotension was evaluated on Post-dialysis reduction in right ventricular free wall strain (RVFWS) (p=0.017). Patients who developed intradialytic hypotension exhibited a significantly greater post-dialysis reduction in right ventricular free wall strain compared to those without hypotension (-7.0% vs -1.7%, P=0.017).
Synapse has enriched 10 related papers. Consider them for comparative context: