Key result
A history of miscarriage was associated with a greater odds of developing coronary heart disease (OR 1.45; 95% CI 1.18-1.78), but not cerebrovascular disease.
Why the study?
Does a history of miscarriage increase the risk of future coronary heart disease and cerebrovascular disease in otherwise healthy women?
Population
10 studies pooling 517,504 otherwise healthy women for coronary heart disease analysis and 134,461 for…
Comparison
History of miscarriage or recurrent miscarriage vs No history of miscarriage
Design
Meta-analysis
Authors
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Miscarriage history was associated with higher coronary heart disease risk; supports guideline inclusion of pregnancy complications but leaves causal validation open.
Meta-Analysis (n=517,504)
Does a history of miscarriage increase the risk of future coronary heart disease and cerebrovascular disease in otherwise healthy women?
Odds Ratio: 1.45 (95% CI 1.18–1.78)
A history of miscarriage, particularly recurrent miscarriage, is significantly associated with an increased risk of future coronary heart disease in women, suggesting it should be considered a female-specific cardiovascular risk factor.
Oliver‐Williams et al. (2013) conducted a meta-analysis in Cardiovascular disease risk (n=517,504). Miscarriage vs. No history of miscarriage was evaluated on Coronary heart disease (OR 1.45, 95% CI 1.18 to 1.78). A history of miscarriage was associated with a greater odds of developing coronary heart disease (OR 1.45; 95% CI 1.18-1.78), but not cerebrovascular disease.
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