Key result
A history of miscarriage was associated with a greater odds of developing coronary heart disease (OR 1.45; 95% CI 1.18-1.78), but not cerebrovascular disease.
Why the study?
Does a history of miscarriage increase the risk of future coronary heart disease and cerebrovascular disease in otherwise healthy women?
Meta-Analysis (n=517,504)
Does a history of miscarriage increase the risk of future coronary heart disease and cerebrovascular disease in otherwise healthy women?
Odds Ratio: 1.45 (95% CI 1.18–1.78)
A history of miscarriage, particularly recurrent miscarriage, is significantly associated with an increased risk of future coronary heart disease in women, suggesting it should be considered a female-specific cardiovascular risk factor.
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Miscarriage history was associated with higher coronary heart disease risk; supports guideline inclusion of pregnancy complications but leaves causal validation open.
Oliver‐Williams et al. (2013) conducted a meta-analysis in Cardiovascular disease risk (n=517,504). Miscarriage vs. No history of miscarriage was evaluated on Coronary heart disease (OR 1.45, 95% CI 1.18 to 1.78). A history of miscarriage was associated with a greater odds of developing coronary heart disease (OR 1.45; 95% CI 1.18-1.78), but not cerebrovascular disease.
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