Key result
Women with two (HR 1.75; 95% CI 1.22-2.52) or three or more (HR 3.18; 95% CI 1.49-6.80) consecutive miscarriages had a significantly increased risk of subsequent ischaemic heart disease.
Why the study?
Does a history of miscarriage increase the risk of subsequent cardiovascular disease in women?
Population
60,105 women with at least one miscarriage or live birth recorded from 1950 to 2010 in the Aberdeen…
Comparison
History of miscarriage vs Women with at least one live birth and no…
Design
Cohort
Authors
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Recurrent miscarriage history may prompt earlier IHD risk assessment in women; leaves open causality versus shared risk factors.
Cohort (n=60,105)
Does a history of miscarriage increase the risk of subsequent cardiovascular disease in women?
Hazard Ratio: 1.75 (95% CI 1.22–2.52)
A history of two or more miscarriages is associated with a significantly increased risk of subsequent ischaemic heart disease in women.
Wagner et al. (2015) conducted a cohort in Cardiovascular disease (n=60,105). History of miscarriage vs. Women with at least one live birth and no miscarriages was evaluated on Ischaemic heart disease (HR 1.75, 95% CI 1.22-2.52). Women with two (HR 1.75; 95% CI 1.22-2.52) or three or more (HR 3.18; 95% CI 1.49-6.80) consecutive miscarriages had a significantly increased risk of subsequent ischaemic heart disease.
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