Key result
Diabetic ketoacidosis in children was associated with a significantly prolonged QTc interval compared to after recovery (mean difference 43 milliseconds; 95% CI 23-63; P<0.001).
Why the study?
Does diabetic ketoacidosis prolong the QTc interval in children?
Population
30 children with type 1 diabetes mellitus and diabetic ketoacidosis (DKA)
Comparison
Diabetic ketoacidosis (DKA) state vs After recovery from DKA (intra-patient comparison)
Design
Cohort
Follow-up
after recovery from DKA
Authors
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May warrant ECG monitoring during pediatric DKA; leaves open arrhythmia risk and need for prospective trials.
Observational (n=30)
No
Does diabetic ketoacidosis prolong the QTc interval in children?
Mean Difference: 43 (95% CI 23–63)
Absolute Event Rate: 450% vs 407%
p-value: p=< .001
Diabetic ketoacidosis is frequently associated with transient QTc prolongation in children, which correlates with the degree of ketosis and resolves upon recovery.
Kuppermann et al. (2008) conducted an observational in Type 1 diabetes mellitus and diabetic ketoacidosis (n=30). Diabetic ketoacidosis vs. After recovery was evaluated on QTc during DKA (MD 43, 95% CI 23-63, p=< .001). Diabetic ketoacidosis in children was associated with a significantly prolonged QTc interval compared to after recovery (mean difference 43 milliseconds; 95% CI 23-63; P<0.001).
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