Key result
Electrolyte abnormalities in patients with Diabetic Ketoacidosis were associated with a higher maximum QTc interval (441.11 ± 16.49) compared to those with normal electrolytes (424.41 ± 21.30).
Why the study?
Diabetic ketoacidosis represents a dangerous manifestation of diabetes mellitus accounting for substantial hospital admissions and fatalities, warranting investigation of QTc interval prolongation with reference to electrolyte imbalances.
Does electrolyte imbalance increase QTc interval prolongation in patients with Diabetic Ketoacidosis?
Observational
No
Does electrolyte imbalance increase QTc interval prolongation in patients with Diabetic Ketoacidosis?
Absolute Event Rate: 441.11% vs 424.41%
Electrolyte imbalances in diabetic ketoacidosis are associated with significant QTc interval prolongation, which may indicate cardiac autonomic neuropathy and predict cardiovascular mortality.
May warrant QTc monitoring in DKA with electrolyte abnormalities; leaves open causal effects on outcomes.
The present study investigate a QTc interval prolongation in diagnosed cases of Diabetic Ketoacidosis with reference to electrolyte imbalances. Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are dangerous manifestations of diabetes mellitus representing two extremes in the spectrum of uncontrolled diabetic state. DKA accounts for 14 percentages of all hospital admissions among diabetics and 16 percentages of all diabetes- related fatalities in India. The study was conducted in the ICU, general medicine ward and casualty under Department of Medicine at tertiary care hospital during August 2020 to July 2022. In present study QTc Maximum mean ±SD found in electrolytes abnormal group was 441.11 ± 16.49 and in electrolytes normal group was 424.41 ± 21.30, QTc Minimum mean ±SD found in electrolytes abnormal group was 393.69 ± 8.24 and in electrolytes normal group was 383.08 ± 15.99. QTc Dispersion mean ±SD found in electrolytes abnormal group was 48.75 ± 9.22 and in electrolytes normal group was 41.63 ± 9.88. QTc Mean mean ±SD found in electrolytes abnormal group was 417.41 ± 12.35 and in electrolytes normal group was 404.65 ± 15.81. It is suggested that QTc interval prolongation is an indicator of CAN (Cardiac Autonomic Neuropathy) and predictive tool for cardio-vascular mortality (worse outcomes) in patients with Diabetic Ketoacidosis.
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Naik et al. (2023) conducted an observational in Diabetic Ketoacidosis. Electrolyte abnormalities vs. Normal electrolytes was evaluated on Maximum QTc interval. Electrolyte abnormalities in patients with Diabetic Ketoacidosis were associated with a higher maximum QTc interval (441.11 ± 16.49) compared to those with normal electrolytes (424.41 ± 21.30).
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