Key result
Prolonged QTc strongly correlates with longer diabetes duration and elevated HbA1c, suggesting non-invasive screening potential.
Why the study?
QTc duration is independently related to cardiovascular disease severity in diabetes, prompting assessment of QTc prolongation as a diagnostic tool for cardiovascular disease in T2DM patients.
Does QTc prolongation correlate with HbA1c and duration of diabetes in patients with type 2 diabetes mellitus?
Cross-Sectional (n=100)
No
Does QTc prolongation correlate with HbA1c and duration of diabetes in patients with type 2 diabetes mellitus?
Effect estimate: AUC 0.782 (95% CI 0.676-0.889)
p-value: p=<0.001
Prolonged QTc interval on ECG correlates with longer duration of diabetes and higher HbA1c, suggesting its potential utility as a noninvasive screening tool for cardiovascular risk in type 2 diabetes.
BACKGROUND The occurrence of QT interval prolongation is higher in subjects with type 2 diabetes mellitus (T2DM). Duration of QT interval corrected (QTc) for heart rate is independently related with severity of cardiovascular diseases in diabetics. This study was proposed to assess the QTc prolongation as a diagnostic tool for cardiovascular disease in T2DM patients. METHODS This study included 100 diabetic patients admitted in wards of a tertiary care center. A thorough clinical examination was carried out for all the patients. Patients were investigated for the fasting blood glucose level, glycated haemoglobin (HbA1c), lipid profile & electrocardiogram (ECG). Data was represented as percentage. Mean and standard deviation (SD) of quantitative variables were tabulated, t test was used for correlation and receiver operating characteristic (ROC) curve was used for evaluating area under curve. P < 0.05 was considered statistically significant. RESULTS Male preponderance was observed. All the study subjects had a prolonged period of diabetes with various metabolic complications. The area under the curve estimation of QTc > 400 ms with respect to HbA1c and duration of diabetes showed significant correlation between longer duration of diabetes and raised HbA1c associated with raised QTc interval (P < 0.05). CONCLUSIONS Diagnosis of prolonged QTc interval could be utilized for estimating cardiovascular risk in diabetes patients. It can be easily assessed on ECG besides being a noninvasive investigation which is also affordable in evaluating the cardiovascular risk in T2DM patients.
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Thorat et al. (2021) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=100). QTc prolongation (> 400 ms) vs. Normal QTc (≤ 400 ms) was evaluated on Area under the ROC curve for QTc > 400 ms with respect to duration of diabetes (AUC 0.782, 95% CI 0.676-0.889, p=<0.001). Prolonged QTc interval (>400 ms) showed a significant correlation with longer duration of diabetes (AUC 0.782) and elevated HbA1c (AUC 0.721), indicating its potential as a non-invasive cardiovascular risk screening tool.
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