Key result
QTc interval prolongation in patients with type 2 diabetes was significantly associated with decreased heart rate variability, including a nearly 4-fold increased odds of being in the lowest quartile of total power (OR 3.99).
Why the study?
The study investigated the association between the heart rate-corrected QT interval and heart rate variability in patients with type 2 diabetes mellitus.
Is QTc interval prolongation associated with decreased heart rate variability in patients with type 2 diabetes?
Population
411 patients with type 2 diabetes mellitus
Comparison
QTc interval prolongation (>440 ms) vs normal QTc interval
Design
Cross-sectional study
Authors
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Association in T2DM may signal autonomic risk; hypothesis-generating and leaves open prognostic value or practice change.
Cross-Sectional (n=411)
No
Is QTc interval prolongation associated with decreased heart rate variability in patients with type 2 diabetes?
Odds Ratio: 3.99 (95% CI 2.29–6.96)
p-value: p=<0.001
In patients with type 2 diabetes, QTc interval prolongation is independently associated with decreased heart rate variability, suggesting a link between abnormal autonomic function and QTc prolongation.
Seon‐Ah Cha (2022) conducted a cross-sectional in Type 2 diabetes mellitus (n=411). QTc interval prolongation (>440 ms) vs. Normal QTc interval (≤440 ms) was evaluated on Lowest quartile of Total Power (TP) heart rate variability (OR 3.99, 95% CI 2.29-6.96, p=<0.001). QTc interval prolongation in patients with type 2 diabetes was significantly associated with decreased heart rate variability, including a nearly 4-fold increased odds of being in the lowest quartile of total power (OR 3.99).
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