Key result
Older age in patients undergoing TAVR was associated with a differential inflammatory response and clinical outcomes (p=0.04 and 0.028), though survival rates were similar to younger patients.
Why the study?
TAVR provokes an early injury response, but whether post-TAVR increases in inflammatory markers differ between octogenarians and younger patients, and whether they associate with adverse outcomes, was unknown.
Does the post-TAVR inflammatory response differ between octogenarians and younger patients, and is it associated with adverse clinical outcomes?
Cohort
Does the post-TAVR inflammatory response differ between octogenarians and younger patients, and is it associated with adverse clinical outcomes?
p-value: p=0.04 and 0.028
Post-TAVR inflammatory responses differ by age and are associated with clinical outcomes, but overall survival remains similar between octogenarians and younger patients.
BACKGROUND: Transcatheter aortic valve replacement (TAVR) provokes an early injury response, partially represented by dynamic changes in inflammatory markers. TAVR greatly benefits the elderly and we aimed to determine whether increased inflammatory markers post-TAVR in octagenerians were different than their younger counterparts and whether it was associated with adverse clinical outcomes. METHODS: Patients with severe symptomatic aortic stenosis who underwent transfemoral TAVR from January 2010 to December 2021 were enrolled. Total white blood cells (WBC) count and subpopulation dynamics were evaluated. RESULTS: values of 0.04 and 0.028, respectively. CONCLUSION: This is the first description of a differential age-related inflammatory response in patients after TAVR, which shows an association between inflammatory markers post procedure and clinical outcome. Nevertheless, survival rates were similar in the elderly population and in younger patients, despite the presence of comorbid conditions.
No takes yet. Share an insight, caveat, or question.
Khadija et al. (2022) conducted a cohort in Severe symptomatic aortic stenosis. Older age (octogenarians) vs. Younger counterparts was evaluated on Inflammatory markers post procedure and clinical outcome (p=0.04 and 0.028). Older age in patients undergoing TAVR was associated with a differential inflammatory response and clinical outcomes (p=0.04 and 0.028), though survival rates were similar to younger patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: