Key result
Newer TAVR devices linked to lower WBC and IL-6 rises versus original Sapien valves.
Why the study?
TAVR technology and delivery systems have rapidly evolved since the original SAPIEN valve, but changes in thromboinflammatory profiles across valve generations required evaluation.
Do newer generation TAVR valves reduce systemic inflammation compared to older generation valves in patients undergoing transfemoral TAVR?
Population
One hundred and forty five patients undergoing transfemoral TAVR
Comparison
Four valve types (Sapien, Sapien XT, Sapien3, or CoreValve)
Authors
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Newer TAVR valves associated with less inflammation should not change practice; hypothesis-generating and requires randomized confirmation.
Observational (n=145)
Do newer generation TAVR valves reduce systemic inflammation compared to older generation valves in patients undergoing transfemoral TAVR?
Newer generation TAVR devices and smaller delivery systems are associated with less systemic inflammation compared to earlier generations, as reflected by lower WBC and IL-6 levels.
Sexton et al. (2018) conducted an observational in Severe aortic stenosis (n=145). Newer generation transcatheter aortic valves (Sapien XT, Sapien3, CoreValve) vs. Original Sapien valve was evaluated on Changes in thromboinflammatory profiles (Platelet count, WBC, IL-6, SAA). Newer generation TAVR devices were associated with lower post-procedure rises in WBC and IL-6 compared to the original Sapien valve, indicating less systemic inflammation.
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