January 1, 2012Open Access
Assessment of inflammatory response to transfemoral transcatheter aortic valve implantation compared to transapical and surgical procedures: a pilot study
Why the study?
Does transfemoral TAVI reduce postprocedural inflammatory response compared to surgical AVR and transapical TAVI in patients undergoing aortic valve replacement?
Population
40 patients evaluated by the 'heart team' undergoing 'uneventful' surgical aortic valve replacement or…
Comparison
Transfemoral transcatheter aortic valve… vs Surgical aortic valve replacement and…
Design
Cohort
Follow-up
48 hours
Authors
Discussion
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Member takes
Implication
Transfemoral TAVI was associated with lower early inflammation; hypothesis-generating and should not yet change procedural selection.
Structured PICO
Does transfemoral TAVI reduce postprocedural inflammatory response compared to surgical AVR and transapical TAVI in patients undergoing aortic valve replacement?
P
Population
40 patients evaluated by the 'heart team' undergoing 'uneventful' surgical aortic valve replacement (AVR) or transcatheter aortic valve implantation (TAVI)
I
Intervention
Transfemoral transcatheter aortic valve implantation (TAVI) using Edwards SAPIEN or Medtronic CoreValve
C
Comparator
Surgical aortic valve replacement (AVR) and transapical TAVI using Edwards SAPIEN
O
Outcome
Levels of high-sensitive C-reactive protein (hs-CRP) and leukocyte counts at 48 hours post-proceduresurrogate
Transfemoral TAVI is associated with a lower postprocedural inflammatory response compared to surgical AVR and transapical TAVI.
Cite This Study
Stähli et al. (2012) studied this question.