Key result
Transapical aortic valve implantation resulted in significantly lower peak plasma levels of IL-6 (111 vs 258 pg/mL) and IL-8 (15 vs 51 pg/mL) compared with conventional aortic valve replacement.
Why the study?
Does transapical aortic valve implantation reduce the systemic inflammatory response compared to conventional aortic valve replacement in patients undergoing aortic valve replacement?
Population
25 patients undergoing aortic valve replacement
Comparison
Transapical aortic valve implantation (TA-AVI) vs Conventional aortic valve replacement (cAVR)
Design
Cohort
Follow-up
until patient's discharge
Authors
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Supports attenuated inflammation with transapical approach; leaves open clinical impact and need for randomized confirmation.
Observational (n=25)
Does transapical aortic valve implantation reduce the systemic inflammatory response compared to conventional aortic valve replacement in patients undergoing aortic valve replacement?
Absolute Event Rate: 111% vs 258%
Transapical aortic valve implantation is associated with a significantly attenuated systemic inflammatory response compared to conventional surgical aortic valve replacement.
Goetzenich et al. (2011) conducted an observational in Aortic valve replacement (n=25). Transapical aortic valve implantation (TA-AVI) vs. Conventional aortic valve replacement (cAVR) was evaluated on Peak plasma IL-6 concentration (pg/mL). Transapical aortic valve implantation resulted in significantly lower peak plasma levels of IL-6 (111 vs 258 pg/mL) and IL-8 (15 vs 51 pg/mL) compared with conventional aortic valve replacement.
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