Key result
SAVR and TA-TAVR elicited a robust pro-inflammatory response compared to TF-TAVR, while TA-TAVR decreased neurocognitive function and SAVR showed potentially detrimental platelet activation.
Why the study?
Does TAVR (transfemoral or transapical) compared to SAVR alter the inflammatory response, coagulation, and neurocognitive function in patients with symptomatic aortic stenosis?
Population
38 patients with symptomatic aortic stenosis
Comparison
Transcatheter aortic valve replacement, either… vs Surgical aortic valve replacement (SAVR) (n=13)
Design
Cohort, nonrandomized
Follow-up
72 hours
Authors
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TF-TAVR may elicit milder inflammation than SAVR or TA-TAVR; leaves open whether access route affects neurocognitive or coagulation outcomes.
Observational (n=38)
No
Does TAVR (transfemoral or transapical) compared to SAVR alter the inflammatory response, coagulation, and neurocognitive function in patients with symptomatic aortic stenosis?
Transfemoral TAVR is associated with a significantly lower early inflammatory response compared to surgical or transapical valve replacement.
Uhle et al. (2017) conducted an observational in Symptomatic aortic stenosis (n=38). Surgical aortic valve replacement (SAVR) or transapical TAVR vs. Transfemoral TAVR was evaluated on Plasma cytokines, acute-phase proteins, coagulation markers, and neurocognitive function. SAVR and TA-TAVR elicited a robust pro-inflammatory response compared to TF-TAVR, while TA-TAVR decreased neurocognitive function and SAVR showed potentially detrimental platelet activation.
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