Key result
Preoperatively decreased eGFR was independently associated with a 23% increased risk of composite 90-day major postoperative complications per 10 mL/min/1.73 m2 reduction (OR 1.232).
Why the study?
Serum creatinine is relatively inaccurate for detecting mild renal dysfunction, leaving unclear the usefulness of preoperative eGFR for predicting complications after cardiovascular surgery in patients with normal serum creatinine.
Does preoperative eGFR predict 90-day major complications better than serum creatinine in adults undergoing elective cardiovascular surgery with normal serum creatinine?
Population
2208 adults with normal serum creatinine undergoing elective cardiovascular surgery
Comparison
Preoperative eGFR vs serum creatinine concentration
Design
Retrospective cohort study
Follow-up
90 days
Authors
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Preop eGFR may refine risk stratification despite normal creatinine; leaves open whether targeted interventions reduce complications.
Cohort (n=2,208)
No
Does preoperative eGFR predict 90-day major complications better than serum creatinine in adults undergoing elective cardiovascular surgery with normal serum creatinine?
Odds Ratio: 1.232 (95% CI 1.148–1.322)
p-value: p=<0.001
Preoperative eGFR is a better predictor of 90-day major complications than serum creatinine in patients undergoing elective cardiovascular surgery who have normal serum creatinine levels.
Jang et al. (2019) conducted a cohort in Cardiovascular surgery with normal serum creatinine (n=2,208). Preoperatively decreased eGFR vs. Higher eGFR was evaluated on Composite of major complications within 90 days after surgery (OR 1.232, 95% CI 1.148-1.322, p=<0.001). Preoperatively decreased eGFR was independently associated with a 23% increased risk of composite 90-day major postoperative complications per 10 mL/min/1.73 m2 reduction (OR 1.232).
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