Key result
Structural analysis of FMDV neutralizing antibodies revealed that different antibodies undergo considerable induced fit to accommodate the major antigenic site A peptide with similar interactions.
Population
Fab fragment of a neutralizing antibody raised against foot-and-mouth disease virus of serotype C1, alone…
Design
Preclinical
Authors
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Induced fit at FMDV site A may guide epitope-focused vaccines; leaves open applicability to antigenic variation across serotypes.
The study reveals that intratypic antigenic variation of FMDV serotype C is due to subtle structural differences affecting antibody recognition while preserving the receptor binding site structure.
Verdaguer et al. (1998) studied Foot-and-mouth disease virus (FMDV). Fab fragment of a neutralizing antibody against FMDV serotype C1 was evaluated on Three-dimensional structures of the Fab fragment alone and complexed to an antigenic peptide. Structural analysis of FMDV neutralizing antibodies revealed that different antibodies undergo considerable induced fit to accommodate the major antigenic site A peptide with similar interactions.