Key result
A PRECISE-DAPT score ≥25 was associated with an increased risk of composite ischaemic events compared to a score <25 (OR 2.16; 95% CI 1.77-2.65).
Why the study?
The PRECISE-DAPT score identifies high bleeding risk after PCI, but its association with ischaemic outcomes remains unclear.
Is a high PRECISE-DAPT score (≥25) associated with an increased risk of ischaemic outcomes in patients taking dual antiplatelet therapy following PCI?
Meta-Analysis (n=54,220)
Is a high PRECISE-DAPT score (≥25) associated with an increased risk of ischaemic outcomes in patients taking dual antiplatelet therapy following PCI?
Odds Ratio: 2.16 (95% CI 1.77–2.65)
A PRECISE-DAPT score ≥25 identifies patients at high risk not only for bleeding but also for ischaemic events and all-cause mortality following PCI.
May inform balanced DAPT decisions weighing ischaemic alongside bleeding risk; confirms broader prognostic value of PRECISE-DAPT in PCI patients.
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Clifford et al. (2021) conducted a meta-analysis in Patients taking dual antiplatelet therapy following percutaneous coronary intervention (n=54,220). PRECISE-DAPT score ≥25 vs. PRECISE-DAPT score <25 was evaluated on composite ischaemic events (OR 2.16, 95% CI 1.77-2.65). A PRECISE-DAPT score ≥25 was associated with an increased risk of composite ischaemic events compared to a score <25 (OR 2.16; 95% CI 1.77-2.65).
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