Targeting DNA interstrand crosslinks repair with synthetic lethality in High-Grade B-Cell Lymphoma

High-grade B-cell lymphomas (HGBCL) are very aggressive malignancies representing 10% of all large B-cell lymphomas (LBCLs), often characterized by overexpression, amplification or rearrangements of the MYC oncogene, genomic instability and chemoresistance [ 1 ]. Genomic alterations of MYC in B-cell lymphomas are often associated with BCL2 overexpression or rearrangements, and constitutive DNA damage response (DDR) pathway activation, which favor B-cell lymphomagenesis by inhibiting MYC -induced apoptosis and attenuating replicative stress, respectively [ 2 ].