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July 15, 2026Biotechnology Progress

A 3D‐printed multi‐well lung‐on‐chip platform with bioprinted stromal compartment for upper airway tissue culture and antiviral drug evaluation

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Authors

PSPriyanka SawantGRGudepalya Renukaiah RudramurthyVKVarun Kailaje

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Overview

Randomized trial evaluates antiviral drug efficacy in a novel lung-on-chip model for respiratory infections.

Key Points

  • This research aims to create a novel lung-on-chip platform that enables effective evaluation of antiviral drugs in upper airway tissues.
  • Developed a six-well 3D-printed lung-on-chip platform using photopolymer resin.
  • Utilized computational fluid dynamics to ensure uniform perfusion across wells.
  • Created a stromal compartment with bioprinted bioink composed of lung fibroblasts and THP-1 monocytes.
  • Achieved physiological barrier integrity with a transepithelial electrical resistance of ~800 Ω·cm².
  • Demonstrated cytokine elevation (IL-6, IL-8) in response to SARS-CoV-2 stimulation and Influenza A infection.
  • Oseltamivir treatment suppressed cytokine release during viral infections.

Cite This Study

Sawant et al. (2026) studied this question.

synapsesocial.com/papers/6a57231a88b21df87547fe77https://doi.org/10.1002/btpr.88538
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