Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 15, 2026CureusOpen Access

Severe Immune-Mediated Thrombotic Thrombocytopenic Purpura With High-Titer ADAMTS13 Inhibitors: A Case Report

View Full Paper
Ask AI
Bookmark
Share

Authors

IRIsabel V RodriguesACAna Pimenta de CastroERElena Rios

Discussion

Loading...

Member takes

Overview

Case report demonstrates rapid remission of iTTP in a patient after multimodal therapy, suggesting effective management strategies.

Key Points

  • To highlight the diagnosis and treatment of severe immune-mediated thrombotic thrombocytopenic purpura (iTTP) due to high-titer ADAMTS13 inhibitors.
  • Case report of a 46-year-old man with constitutional symptoms, severe thrombocytopenia, and microangiopathic hemolytic anemia.
  • Assessment using PLASMIC score indicating severe ADAMTS13 deficiency, confirmed with laboratory tests.
  • Interventions included therapeutic plasma exchange, corticosteroids, caplacizumab, and rituximab.
  • PLASMIC score of 7 indicated high probability of severe ADAMTS13 deficiency.
  • Therapeutic interventions resulted in rapid hematologic remission post-treatment.
  • Extensive diagnostic workup ruled out other thrombotic microangiopathies.

Cite This Study

Rodrigues et al. (2026) studied this question.

synapsesocial.com/papers/6a57236f88b21df8754801e2https://doi.org/10.7759/cureus.112586
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA: PATHOPHYSIOLOGY, DIAGNOSIS AND OPEN ISSUES.2024 · 5 citations
  2. 2Treatment of immune-mediated thrombotic thrombocytopenic purpura without plasma exchange2024 · 2 citations
  3. 3Survival and relapse in patients with thrombotic thrombocytopenic purpura2009 · 572 citations
  4. 4Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura2019 · 1,037 citations
  5. 5Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura2016 · 675 citations