What question did this study set out to answer?

This study aims to clarify how specific SNP variants affect gene and protein expression in systemic lupus erythematosus (SLE).

July 15, 2026BMC ImmunologyOpen Access

Deciphering the role of SNP variants of co-stimulatory genes in systemic lupus erythematosus: from genotype to protein expression

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial investigates genetic influence on protein expression in systemic lupus erythematosus, suggesting regulatory variants.

This study aims to clarify how specific SNP variants affect gene and protein expression in systemic lupus erythematosus (SLE).
Included 38 SLE patients and 34 healthy controls.
Assessed CD28, CTLA-4, and PD-1 expression on CD3+CD4+ cells using flow cytometry after cell stimulation.
Evaluated associations between SNP genotypes and protein expression using the Mann-Whitney U test.
GT genotype of CD28 rs1879877 linked to increased CD3+CD28+ expression in SLE (p=0.017).
TT genotype of CTLA4 rs733618 linked to increased cell percentage (p=0.007 in SLE, 0.011 combined).
CC genotype of rs36084323 and GG genotype of rs2227982 associated with increased PD-1 expression (p=0.014 in SLE, 0.002 and 0.001 combined).

Chen et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark