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July 15, 2026Endocrinology and MetabolismOpen Access

Dietary Index for Gut Microbiota, Plasma Metabolic Signature, and Risk of All-Cause and Cardiovascular Disease Mortality

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Authors

YLYingxin LiaoYDY F DengCYChao Yu

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Overview

Randomized trial associates dietary index and metabolic signature with lower mortality risk, suggesting dietary patterns impact health.

Key Points

  • Investigate associations among dietary index for gut microbiota, metabolic signature, and mortality risk from all causes and cardiovascular disease.
  • Analyzed data from two cohort studies, UK Biobank (N=170,575) and US National Health and Nutrition Examination Survey (N=26,651).
  • Calculated dietary index using 24-hour dietary recall questionnaire data.
  • Assessed associations with Cox proportional hazards regression model.
  • Highest dietary index group had lower all-cause mortality risk with HR 0.86 (P<0.001) in the UK cohort and HR 0.79 (P<0.001) in the US cohort.
  • Lower CVD mortality risk with HR 0.79 (P=0.013) in the UK cohort and HR 0.68 (P=0.007) in the US cohort.
  • Identified 124 metabolites associated with all-cause mortality risk (HR 0.68, P<0.001) and CVD mortality risk (HR 0.65, P=0.003).

Cite This Study

Liao et al. (2026) studied this question.

synapsesocial.com/papers/6a5723c288b21df8754806e5https://doi.org/10.3803/enm.2025.2787
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