What question did this study set out to answer?

To explore the relationship between local wall shear stress and plaque features in carotid artery disease.

July 15, 2026Cerebrovascular Diseases

Association of Local Wall Shear Stress with Plaque Features in Carotid Artery Disease: Insights from Histopathological and Neutrophil Extracellular Trap Analysis

View Full Paper

Ask AI

Bookmark

Authors

KSKoji Shimonaga NYNaoto Yamada JOJunichiro Ochiai

Discussion

Member takes

Overview

Observational study examines plaque characteristics linked to wall shear stress in carotid artery disease, suggesting implications for plaque biology.

Key Points

To explore the relationship between local wall shear stress and plaque features in carotid artery disease.
Single-center observational study
Analyzed data from 49 patients undergoing carotid endarterectomy
Used computational fluid dynamics to quantify wall shear stress.
WSS_min associated with ulcerated plaques and symptomatic presentation, particularly in ulcerated lesions.
WSS_max correlated with stenosis severity and prevalent in asymptomatic lesions.
Higher NET accumulation observed in WSS_min regions compared to WSS_max regions.

Cite This Study

Shimonaga et al. (2026) studied this question.

synapsesocial.com/papers/6a5723fd88b21df8754807cb https://doi.org/10.1159/000553502

View Full Paper

Ask AI

Bookmark

July 15, 2026Cerebrovascular Diseases

Association of Local Wall Shear Stress with Plaque Features in Carotid Artery Disease: Insights from Histopathological and Neutrophil Extracellular Trap Analysis

View Full Paper

Ask AI

Bookmark

Authors

KSKoji Shimonaga NYNaoto Yamada JOJunichiro Ochiai

Discussion

Member takes

Overview

Observational study examines plaque characteristics linked to wall shear stress in carotid artery disease, suggesting implications for plaque biology.

Key Points

To explore the relationship between local wall shear stress and plaque features in carotid artery disease.
Single-center observational study
Analyzed data from 49 patients undergoing carotid endarterectomy
Used computational fluid dynamics to quantify wall shear stress.
WSS_min associated with ulcerated plaques and symptomatic presentation, particularly in ulcerated lesions.
WSS_max correlated with stenosis severity and prevalent in asymptomatic lesions.
Higher NET accumulation observed in WSS_min regions compared to WSS_max regions.

Cite This Study

Shimonaga et al. (2026) studied this question.

synapsesocial.com/papers/6a5723fd88b21df8754807cb https://doi.org/10.1159/000553502

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark