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July 9, 2014PLoS ONEOpen Access

Increasing carotid stenosis severity in vitro elevated free shear stress to 2-16 Pa and wall shear stress to 4-36 Pa, with plaque eccentricity and ulceration further altering stress distributions.

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Population

In vitro family of eight matched-geometry models of the carotid artery incorporating independently varied…

Comparison

Particle image velocimetry to measure shear stress vs Comparison among models with different stenosis…

Design

Preclinical

Key result

Increasing carotid stenosis severity in vitro elevated free shear stress to 2-16 Pa and wall shear stress to 4-36 Pa, with plaque eccentricity and ulceration further altering stress distributions.

Authors

SKSarah KefayatiJMJaques S. MilnerDHDavid W. Holdsworth

Discussion

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Overview

Should not guide clinical carotid stenosis management; leaves open hemodynamic contributions to human plaque vulnerability.

Structured PICO

P
Population
In vitro family of eight matched-geometry models of the carotid artery incorporating independently varied plaque features (stenosis severity up to 70%, plaque eccentricity, plaque ulceration)
I
Intervention
Particle image velocimetry to measure shear stress
C
Comparator
Comparison among models with different stenosis severity, plaque eccentricity, and presence of ulceration
O
Outcome
Levels and patterns of shear stress (laminar and turbulent phases, free shear stress, wall shear stress)surrogate

In vitro carotid artery models demonstrate that stenosis severity, plaque eccentricity, and ulceration significantly alter local shear stress patterns, which may contribute to plaque vulnerability and cerebrovascular events.

Cite This Study

Kefayati et al. (2014) studied Carotid artery stenosis (n=8). Varied plaque features (stenosis severity, eccentricity, ulceration) was evaluated on Levels and patterns of shear stress (free shear stress and wall shear stress). Increasing carotid stenosis severity in vitro elevated free shear stress to 2-16 Pa and wall shear stress to 4-36 Pa, with plaque eccentricity and ulceration further altering stress distributions.

synapsesocial.com/papers/6a12577cea48cb855a34a06chttps://doi.org/10.1371/journal.pone.0098209
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Computational and experimental assessment of influences of hemodynamic shear stress on carotid plaque2017 · 22 citations
  2. 2Exploring the Relationships Between Hemodynamic Stresses in the Carotid Arteries2021 · 14 citations
  3. 3Study of the effect of stenosis severity and non-Newtonian viscosity on multidirectional wall shear stress and flow disturbances in the carotid artery using particle image velocimetry2019 · 40 citations
  4. 4Wall Shear Stress Analysis in Stenosed Carotid Arteries with Different Shapes of Plaque2016 · 8 citations
  5. 5Association of Local Wall Shear Stress with Plaque Features in Carotid Artery Disease: Insights from Histopathological and Neutrophil Extracellular Trap Analysis2026