Why the study?
Carotid bifurcation atherosclerosis is influenced by local variations in wall shear stress magnitude, direction, and flow complexity.
Population
Idealized carotid bifurcation models with varying eccentric internal carotid artery stenosis
Comparison
Non-Newtonian vs Newtonian blood analogues across varying stenosis severities
Design
In vitro stereoscopic particle image velocimetry study
Key result
Compared to Newtonian fluids, non-Newtonian blood analogues reduced mean oscillatory shear index by 9-19% and predicted smaller regions of low and oscillatory wall shear stress in carotid models.
Authors
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Non-Newtonian fluid models alter carotid shear predictions; leaves open improved clinical risk stratification pending human validation.
Using a physiological non-Newtonian fluid model alters predicted wall shear stress and flow disturbances in carotid bifurcation models compared to a Newtonian assumption.
DiCarlo et al. (2019) studied Carotid artery stenosis. Non-Newtonian (nN-fluid) blood analogues vs. Newtonian (N-fluid) blood analogues was evaluated on Multidirectional wall shear stress (WSS) and disturbed flow metrics (TI, TAWSS, OSI, transWSS). Compared to Newtonian fluids, non-Newtonian blood analogues reduced mean oscillatory shear index by 9-19% and predicted smaller regions of low and oscillatory wall shear stress in carotid models.
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