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July 15, 2026BiomoleculesOpen Access

The ZFP36 Family as a Post-Transcriptional Immune Checkpoint in Immunity and Disease: Molecular Mechanisms and Functional Implications

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Authors

YYYi YangWZWenhao ZhongQHQiang Huang

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Overview

Review highlights the role of ZFP36 family in immune modulation and disease mechanisms, indicating therapeutic potential.

Key Points

  • This review aims to explore the ZFP36 family as a post-transcriptional immune checkpoint and its implications in immunity and disease.
  • Examined structural features and mechanisms of ZFP36 family proteins.
  • Reviewed roles in various immune responses and disease contexts.
  • Discussed implications for cancer and inflammatory diseases regarding ZFP36 modulation.
  • ZFP36 proteins regulate immune responses by modulating mRNA levels and stability.
  • Context-dependent roles in cancer include tumor suppression and potential immune evasion.
  • ZFP36 family modulation presents opportunities and challenges for therapeutic approaches.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a57245a88b21df875480bd4https://doi.org/10.3390/biom16071023
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