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September 23, 2025Open Access

ZFP36 as a Key Regulator of CD4+ T Cell Subset Balance in Immune Checkpoint Inhibitor-Induced Adverse Events in Lung Adenocarcinoma

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Authors

QGQuanwei GongXHXianda HuangCZChunyan Zhou

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Overview

Single-cell RNA sequencing uncovers ZFP36's crucial influence on CD4+ T cells, highlighting its potential in predicting immune checkpoint inhibitor-related adverse events.

Key Points

  • ZFP36 downregulation leads to Th17/Treg imbalance, contributing to susceptibility to immune-related adverse events.
  • Single-cell RNA analysis showed significantly lower ZFP36 in irAE patients compared to irAE-free patients, with a p-value of less than 0.001.
  • The study employed single-cell RNA sequencing and flow cytometry to analyze CD4+ T cell differentiation and ZFP36's functional role.
  • ZFP36 serves as a potential biomarker for predicting irAE risk and immunotherapy response in lung adenocarcinoma patients.

Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68d4759931b076d99fa6da81https://doi.org/10.21203/rs.3.rs-7339858/v1
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