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December 8, 2025Blood

ZFP36L2 as a promising therapeutic target in acute graft-versus-host disease: Evidence from murine models and clinical validation

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Authors

XTXiwen TongBXBin XuWJWei Jia

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Overview

Murine models and clinical validation demonstrate ZFP36L2's role in regulatory T cells and acute graft-versus-host disease.

Key Points

  • To investigate ZFP36L2 as a potential therapeutic target in acute graft-versus-host disease (aGVHD).
  • Conducted single-cell transcriptomics of patient CD3+ T cells using scRNA-seq.
  • Utilized a murine model of aGVHD with C57BL/6 donors and BALB/c recipients.
  • Performed qPCR, immunohistochemistry, and Western blot to assess ZFP36L2 expression.
  • Administered rapamycin to evaluate its effect on ZFP36L2 expression and immune response.
  • Identified ZFP36L2 as downregulated in aGVHD patients' regulatory T cells.
  • ZFP36L2 expression decreased in aGVHD target organs in murine models.
  • Rapamycin administration upregulated ZFP36L2 expression and improved Treg proportions.

Cite This Study

Tong et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6e0https://doi.org/10.1182/blood-2025-5863
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low expression of ZFP36L2 causes glucocorticoid resistance in childhood T-cell acute lymphoblastic leukemia2026
  2. 2Development of a Protective Cellular Therapy to Prevent Graft Versus Host Disease Post Allogenic Hematopoietic Stem Cell Transplant 23319392026
  3. 3ZFP36 as a Key Regulator of CD4+ T Cell Subset Balance in Immune Checkpoint Inhibitor-Induced Adverse Events in Lung Adenocarcinoma2025
  4. 4Suppression of P53 Pathway is an Important Factor Inducing Acute Graft-versus-Host Disease Through T Cell Activation Based on Bioinformatics Analysis2024 · 1 citations
  5. 5NLRP6 regulates ZAP-70-erk signaling in both murine and human T cells and influences acute graft-versus-host disease(GVHD)2025