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December 8, 2025BloodOpen Access

NLRP6 regulates ZAP-70-erk signaling in both murine and human T cells and influences acute graft-versus-host disease(GVHD)

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Authors

JGJana GawronHFHideaki FujiwaraYIYuki Ishizawa

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Overview

Research demonstrates that Nlrp6 regulates erk signaling and acute graft-versus-host disease in T cells, indicating a role in immune responses.

Key Points

  • The aim was to explore the role of Nlrp6 in T cell signaling and graft-versus-host disease.
  • Examined Nlrp6 expression in T cells of patients with acute graft-versus-host disease
  • Assessed TCR signal transduction pathways focusing on Zap-70 and Erk activation
  • Utilized murine models to analyze T cell activity in aGVHD
  • Investigated effect of Nlrp6 deficiency on immunological responses and characteristics of T cells
  • Measured levels of granzyme B and other cytotoxic molecules in Nlrp6-/- and WT T cells.
  • Nlrp6 regulates signaling pathways associated with T cell responses in acute graft-versus-host disease.
  • Nlrp6 deficiency led to increased phosphorylated Zap-70 and Erk levels in T cells.
  • There were no significant differences in granzyme B production between Nlrp6-/- and WT T cells, indicating similar cytotoxic responses.
  • Decreased Nlrp6 expression was associated with aGVHD in human T cells, mirroring findings in murine models.
  • Nlrp6 plays a crucial role in modulating immune responses relevant to graft-versus-host disease.

Cite This Study

Gawron et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9b7https://doi.org/10.1182/blood-2025-4090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NLRP6 regulates donor T cell activation and acute graft-<i>versus</i>-host disease via ZAP-70-Erk pathway2026
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  3. 3The role of NFAT-deficient T cells in preventing acute GVHD and the immune-mediated protection against Cytomegalovirus infection in allogeneic stem cell transplantation2025
  4. 4ZFP36L2 as a promising therapeutic target in acute graft-versus-host disease: Evidence from murine models and clinical validation2025
  5. 5Ornithine decarboxylase deficiency in donor T cells preserves strong GVL activity while attenuating acute and preventing steroid-resistant gut GVHD in a recipient tissue PD-L1-dependent manner2025