Key result
Postmenopausal women exhibit lower orthostatic tolerance than similar-age men after two weeks of bed rest.
Why the study?
Do postmenopausal women and similar-age men differ in their response to orthostatic stress following 2 weeks of bed rest?
Observational
Do postmenopausal women and similar-age men differ in their response to orthostatic stress following 2 weeks of bed rest?
Postmenopausal women and similar-age men exhibit different physiological mechanisms underlying reduced cerebral perfusion and orthostatic tolerance after prolonged bed rest.
Postmenopausal women had lower orthostatic tolerance than similar-age men while standing post-bed rest. Both sexes exhibited lower cerebral blood velocity nadirs upon standing; however, sex-specific interactions of the determinants of cerebral perfusion (i.e., Pco 2 , cerebrovascular resistance index, and arterial pressure) were observed during prolonged standing after bed rest. These results indicate that postmenopausal women and men have different factors underlying reduced cerebral perfusion while standing after bed rest.
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Hedge et al. (2024) conducted an observational in Orthostatic stress following bed rest. Female sex (postmenopausal) vs. Similar-age men was evaluated on Orthostatic tolerance and cerebral perfusion while standing post-bed rest. Postmenopausal women exhibited lower orthostatic tolerance and different factors underlying reduced cerebral perfusion compared to similar-age men while standing after 2 weeks of bed rest.
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