Key result
Older women showed higher sympathetic and lower parasympathetic activity at rest compared to men, with no significant sex differences in hemodynamic responses to orthostatic challenge.
Why the study?
Premenopausal women show a higher incidence of orthostatic hypotension than men, but data on sex differences in cardiovascular responses to orthostatic challenge in healthy older persons are limited.
Are there sex differences in hemodynamic and autonomic responses to orthostatic challenge in healthy older persons?
Comparison
Older women vs age-matched men during a sit-to-stand test
Design
Pilot study
Authors
Loading...
Hypothesis-generating for sex differences in older adults' orthostatic responses; larger studies needed to confirm clinical relevance.
Cross-Sectional (n=24)
No
Are there sex differences in hemodynamic and autonomic responses to orthostatic challenge in healthy older persons?
Absolute Event Rate: 70.2% vs 52.3%
p-value: p=<0.05
Older women exhibit higher sympathetic and lower parasympathetic activity at rest compared to men, contradicting previous observations of reduced sympathetic activity in women.
Sachse et al. (2019) conducted a cross-sectional in Healthy older persons (n=24). Female sex vs. Male sex was evaluated on Normalized low-frequency power (LFnuRRI) at baseline (p=<0.05). Older women showed higher sympathetic and lower parasympathetic activity at rest compared to men, with no significant sex differences in hemodynamic responses to orthostatic challenge.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: