Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study

Hengmin Xu; Hui Ma; Yuxin Wang; Xinling Wang; Xuan Han; Wenjing Zhao; Yang Zhang; Tong Zhou; Jingying Zhang; Weicheng You; Wenqing Li; Kaifeng Pan

doi:10.20892/j.issn.2095-3941.2026.0145

July 14, 2026Cancer Biology and MedicineOpen Access

Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study

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Key Points

This research examines the relationship between genetic susceptibility, environmental risk factors, and the risk of gastric cancer in the context of Helicobacter pylori infection status.
Population-based design analyzing different H. pylori infection statuses
Assessment of genetic and environmental risk factors
Comparative analysis of incident gastric cancer cases across infection statuses
Gastric cancer risk is significantly influenced by genetic factors and environmental exposures, even in H. pylori-negative individuals
Alternative pathways to gastric cancer are suggested for those without active H. pylori infection
Findings indicate that both genetic and environmental influences are important in understanding gastric cancer development

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Implication

Population-based study investigates gastric cancer risk linked to genetic and environmental factors, indicating complex interactions beyond H. pylori infection.

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Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a5874652b46c88ba9ad0943 https://doi.org/10.20892/j.issn.2095-3941.2026.0145

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Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study

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Discussion

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Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study

Key Points

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Cite This Study

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