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This research examines the relationship between genetic susceptibility, environmental risk factors, and the risk of gastric cancer in the context of Helicobacter pylori infection status.

July 16, 2026Cancer Biology and Medicine0 citationsOpen Access

Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study

HXHengmin XuPeking University HMHui MaPeking University YWYuxin WangPeking University

Key Points

This research examines the relationship between genetic susceptibility, environmental risk factors, and the risk of gastric cancer in the context of Helicobacter pylori infection status.
Population-based design analyzing different H. pylori infection statuses
Assessment of genetic and environmental risk factors
Comparative analysis of incident gastric cancer cases across infection statuses
Gastric cancer risk is significantly influenced by genetic factors and environmental exposures, even in H. pylori-negative individuals
Alternative pathways to gastric cancer are suggested for those without active H. pylori infection
Findings indicate that both genetic and environmental influences are important in understanding gastric cancer development

Abstract

Gastric cancer (GC) remains a leading cause of cancer mortality worldwide11. Helicobacter pylori (H. pylori) infection is the dominant etiologic factor22, yet GC also arises in individuals without infection or after eradication, suggesting alternative carcinogenic pathways33. Accordingly

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