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February 21, 2026Digestion

Gastric cancer in the post Helicobacter pylori era – non-H. pylori-related gastric microbiota, non-H. pylori related and post-H. pylori eradication gastric cancer

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Authors

ATAlai TanMin-Hwei College of Health Care ManagementNTNicholas Chin Hock TeeSingHealthTATiing Leong Ang

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Implication

This narrative review evaluates gastric cancer mechanisms associated with non-H. pylori factors, suggesting new diagnostic pathways.

Key Points

  • The review aims to assess the role of non-H. pylori gastric microbiota in gastric cancer development and related clinical aspects.
  • Narrative literature review of existing studies on non-H. pylori gastric microbiota and gastric cancer.
  • Evaluation of case-control studies on the gastric microbiome associated with gastric cancer.
  • Analysis of mechanistic studies using mice models to understand microbial influence on gastric carcinogenesis.
  • Dysbiosis of the gastric microbiome linked to gastric cancer includes higher levels of Fusobacterium nucleatum and others.
  • Chronic atrophic gastritis and gastric intestinal metaplasia increase gastric cancer risk even after H. pylori eradication.
  • Epidemiological data suggest hereditary factors and autoimmune disorders contribute to gastric cancer risk.

Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/69994cd2873532290d021921https://doi.org/10.1159/000551095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Asian Pacific Association of Gastroenterology task force recommendations on surveillance for Helicobacter pylori associated gastric premalignant conditions2025 · 13 citations
  2. 2Multi-omics analysis reveals disrupted gut microbiota and metabolism in gastric cancer patients with high SIRI2025 · 4 citations
  3. 3Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta-analysis2016 · 1,047 citations
  4. 4Management and clinical outcomes of type I gastric carcinoid patients: R etrospective, multicenter study in J apan2013 · 65 citations
  5. 5Predictive Value of a Gastric Microbiota Dysbiosis Test for Stratifying Cancer Risk in Atrophic Gastritis Patients2024 · 13 citations