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November 13, 2025Chinese Medical JournalOpen Access

Helicobacter pylori infection status and evolution of gastric cancer

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Authors

WZWenlin ZhangYZYuxin ZhangJNJing Ning

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Overview

Review explores pathogenic mechanisms and risk factors for gastric cancer linked to H. pylori and its absence.

Key Points

  • To review the mechanisms of gastric cancer associated with H. pylori infection status and identify high-risk individuals.
  • Review of pathogenic mechanisms related to H. pylori and gastric cancer.
  • Examination of host factors such as genetic susceptibility and immune microenvironment.
  • Analysis of risk factors associated with H. pylori-negative gastric cancer.
  • Identified several pathogenic mechanisms for gastric cancer linked to H. pylori infection.
  • Discussed increasing cases of gastric cancer in H. pylori-negative individuals.
  • Outlined potential risk factors including autoimmune gastritis and genetic mutations.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/692523c6c0ce034ddc35504fhttps://doi.org/10.1097/cm9.0000000000003903
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gastric cancer in the post Helicobacter pylori era – non-H. pylori-related gastric microbiota, non-H. pylori related and post-H. pylori eradication gastric cancer2026
  2. 2Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study2026
  3. 3Epigenetic alterations in Helicobacter pylori infection leading to gastric carcinogenesis: A systematic review2025 · 5 citations
  4. 4Effects of Helicobacter pylori infection on gastric cancer, obesity and esophageal diseases: a systematic review and meta-analysis2025 · 2 citations
  5. 5Helicobacter Pylori: Gastric Carcinoma and Other Gastrointestinal Neoplasms2024