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July 16, 2026Neuro-OncologyOpen Access

FUS-mediated BBB opening reshapes plasma extracellular vesicle size distribution without elevating concentration in glioblastoma patients

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Authors

MBMassimiliano Del BeneDODaniela OstiMBMarta Bonada

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Overview

Randomized trial evaluates FUS-mediated BBBO effects on extracellular vesicle size and cfDNA profiles in glioblastoma patients, suggesting focused ultrasound strategies may enhance liquid biopsy...

Key Points

  • This study aims to assess how focused ultrasound-mediated blood-brain barrier opening affects plasma extracellular vesicle size and cell-free DNA profiles in glioblastoma patients.
  • Conducted 14 MR-guided focused ultrasound BBBO procedures in glioblastoma patients.
  • Collected blood samples 1 hour before and after sonication for analysis of extracellular vesicles and cfDNA.
  • Utilized size-exclusion chromatography and tunable resistive pulse sensing for extracellular vesicle quantification.
  • EV concentration showed no consistent change post-FUS-BBBO, indicating inter-patient variability.
  • Observed a reproducible size reduction of ∼8-10 nm in EVs, particularly in larger vesicle subpopulations.
  • No significant relationship detected between biomarker changes and procedural parameters, aside from the treated volume.

Cite This Study

Bene et al. (2026) studied this question.

synapsesocial.com/papers/6a5874972b46c88ba9ad0a3chttps://doi.org/10.1093/neuonc/noag155
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 3341: Focused ultrasound BBB opening yields distinct, tissue-specific extracellular vesicle profiles for glioblastoma liquid biopsy2026
  2. 2Focused Ultrasound for Blood-Brain Barrier Opening In Brain Tumor Patients: Technical Nuances2026 · 1 citations
  3. 3Extracellular vesicle response following focused ultrasound-mediated blood–brain barrier opening for the detection of Alzheimer’s pathology2024
  4. 4Microbubble-enhanced and activity-informed FUS liquid biopsy in infiltrating gliomas2024
  5. 5Focused Ultrasound-Enhanced Liquid Biopsy: A Promising Diagnostic Tool for Brain Tumor Patients2024 · 12 citations