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July 16, 2026GERMSOpen Access

Pre-Transplant Antibiotic Exposures and Intestinal Microbiome Diversity in Allo-HSCT Recipients: A Prospective Cohort Study

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Authors

LLLavinia-Eugenia LipanCarol Davila University of Medicine and PharmacyKVKarina-Doris VihtaMinisterul SanatatiiAMAndra-Daniela MarcuCarol Davila University of Medicine and Pharmacy

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Implication

Prospective cohort study examines how antibiotic use impacts gut microbiome diversity in allo-HSCT recipients, suggesting implications for pre-transplant care.

Key Points

  • To assess the relationship between pre-transplant antibiotic exposures and gut microbiome diversity in allo-HSCT patients.
  • Conducted a prospective cohort study with 52 allo-HSCT recipients and 27 healthy controls at a single center.
  • Collected fecal samples before conditioning and analyzed them using 16S rRNA gene sequencing and QIIME2.
  • Applied Wilcoxon test, multivariable linear regression, and PERMANOVA for statistical evaluation.
  • Shannon diversity was significantly lower in allo-HSCT patients (median 4.71) compared to healthy controls (median 6.09; p < 0.001).
  • Carbapenem and oxazolidinone exposures were associated with reduced diversity (p adj = 0.02 and 0.005, respectively).
  • Immunotherapy linked to higher diversity (p adj = 0.042); overall antibiotic model was significant (p = 0.039) but no class-specific associations remained after adjustment.

Cite This Study

Lipan et al. (2026) studied this question.

synapsesocial.com/papers/6a58752d2b46c88ba9ad1050https://doi.org/10.3390/germs16030017
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Also Consider

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  1. 1The impact of different antimicrobial exposures on the gut microbiome in the ARMORD observational study2024 · 7 citations
  2. 2Prevalence and Molecular Epidemiology of Intestinal Colonization by Multidrug-Resistant Bacteria among Hematopoietic Stem-Cell Transplantation Recipients: A Bulgarian Single-Center Study2024 · 5 citations
  3. 3Characterization of Antibiotic Administration Factors Associated with Microbiome Disruption and Subsequent Antibiotic-Resistant Infection and Colonization Events in Acute Myeloid Leukemia Patients Receiving Chemotherapy2025 · 4 citations
  4. 4Impact of Antibiotic Treatment on the Gut Microbiome and its Resistome in Hematopoietic Stem Cell Transplant Recipients2023 · 26 citations
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