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Case report reveals ischiopubic synchondrosis syndrome mimicking recurring Langerhans cell histiocytosis in a child, suggesting careful evaluation is critical.
An 8-year-old girl with previously treated multifocal osseous Langerhans cell histiocytosis presented with right groin and low back pain during surveillance. 18 F Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) demonstrated FDG-avid lesions at the right ischiopubic synchondrosis and L4 vertebra, raising concern for recurrent skeletal involvement. Magnetic resonance imaging (MRI) showed corresponding structural abnormalities, and biopsy of the pubic lesion revealed no evidence of Langerhans cells. 18 F-FDG PET/CT performed 5 months later demonstrated complete resolution of the abnormalities after conservative management. Based on the findings mentioned above, the lesion was diagnosed as ischiopubic synchondrosis syndrome (Van Neck–Odelberg disease), representing an important false-positive pitfall on paediatric oncologic PET/CT.
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Wang et al. (2026) studied this question.
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