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August 20, 2025ChildrenOpen Access

Value of 18F-FDG PET/CT Scans in Staging and Follow-Up of Pediatric Langerhans Cell Histiocytosis: Comparison to CT and/or MRI

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Retrospective analysis highlights the utility of 18F-FDG PET/CT for staging and reactivation monitoring in pediatric LCH compared to CT and MRI.

18F-FDG PET/CT shows excellent concordance with CT and MRI in staging and follow-up.
In a study of 39 children, 18F-FDG PET/CT provided valuable metabolic information at initial staging.
Retrospective analysis conducted from June 2007 to December 2022 assessed imaging modalities in pediatric LCH.
Results suggest further investigation is needed to confirm the advantages of 18F-FDG PET/CT in clinical practice.

Esquivel et al. (2025) studied this question.

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Retrospective analysis highlights the utility of 18F-FDG PET/CT for staging and reactivation monitoring in pediatric LCH compared to CT and MRI.