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September 10, 2025Frontiers in MedicineOpen Access

A clinical study incorporating multimodal 18F-FDG PET/CT metabolic parameters, genetic markers, and clinical characteristics for the evaluation and prediction of treatment efficacy and prognosis in Langerhans cell histiocytosis

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Authors

ZHZizhen HuangUniversity of Science and Technology of China WQWanling QiFirst Affiliated Hospital of Jiangxi Medical College TRT. Rajeswara RaoWenzhou Medical University

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Implication

Retrospective analysis evaluated treatment efficacy and prognosis in LCH using 18F-FDG PET/CT metabolic parameters and genetic markers, indicating critical predictive insights.

Key Points

Metabolic parameters derived from 18F-FDG PET/CT help predict treatment efficacy and prognosis in langerhans cell histiocytosis.
Patients with disease progression exhibited higher SUVmax, TLR, MTV, and TLG values compared to treatment responders.
Univariate and multivariate analyses identified MTV and TLG as independent predictors of progression-free survival.
Increased metabolic parameters suggest an elevated risk for recurrence, emphasizing the need for comprehensive monitoring.

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Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c187179b7b07f3a06109dd https://doi.org/10.3389/fmed.2025.1619967

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Implication

Retrospective analysis evaluated treatment efficacy and prognosis in LCH using 18F-FDG PET/CT metabolic parameters and genetic markers, indicating critical predictive insights.

A clinical study incorporating multimodal 18F-FDG PET/CT metabolic parameters, genetic markers, and clinical characteristics for the evaluation and prediction of treatment efficacy and prognosis in Langerhans cell histiocytosis

Discussion

Member takes

Implication

Key Points

Cite This Study

A clinical study incorporating multimodal 18F-FDG PET/CT metabolic parameters, genetic markers, and clinical characteristics for the evaluation and prediction of treatment efficacy and prognosis in Langerhans cell histiocytosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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