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July 16, 2026Progress in Transplantation

Anxiety and perceived barriers correlate with treatment nonadherence affecting ~60% of post-cardiac transplant patients.

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Why the study?

The study was conducted to examine how psychological and cognitive indicators associate with treatment nonadherence following heart transplantation.

Are psychological and cognitive factors associated with treatment nonadherence in post-cardiac transplant patients?

Population

74 heart transplant patients assessed at least 6 months post-transplant

Comparison

Psychological and cognitive factors vs treatment nonadherence

Design

Single-center cross-sectional exploratory study

Key result

Anxiety symptoms and patient-level perceived barriers were associated with treatment nonadherence, which was observed in 59.5% of post-cardiac transplant patients.

Authors

RVRosemary Inácio VianaEREduardo RemorLGLívia Adams Goldraich

Discussion

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Overview

Anxiety linked to nonadherence post-transplant; hypothesis-generating for screening, needs prospective trials before practice change.

Key Points

  • To examine the link between psychological and cognitive factors and treatment nonadherence post-heart transplantation.
  • Cross-sectional exploratory study conducted in a single heart transplant center
  • Included 74 heart transplant patients assessed at least 6 months after transplantation
  • Used various instruments for assessing anxiety, depression, cognitive function, and adherence
  • Observed nonadherence in 59.5% (n=44) of participants over the past month
  • Anxiety symptoms (GAD-7) and perceived barriers linked to nonadherence (BAASIS)
  • 64.9% (n=48) of patients had complications after transplant, emphasizing the need for supportive care

Study Design

Type

Cross-Sectional (n=74)

Multicenter

No

Structured PICO

Are psychological and cognitive factors associated with treatment nonadherence in post-cardiac transplant patients?

P
Population
74 heart transplant patients assessed at least 6 months post-transplantation to evaluate psychological and cognitive factors associated with treatment nonadherence.
E
Exposure
Assessment of psychological and cognitive indicators (GAD-7, PHQ-9, MoCA-B, perceived barriers).
O
Outcome
Treatment nonadherence to immunosuppressant medications (measured by BAASIS) and its association with psychological and cognitive factors.patient reported

Anxiety and perceived barriers are associated with immunosuppressant nonadherence in heart transplant recipients, highlighting the need for psychological screening.

Cite This Study

Viana et al. (2026) conducted a cross-sectional in Post-cardiac transplant (n=74). Psychological and cognitive factors (anxiety, depression, cognitive impairment, perceived barriers) was evaluated on Treatment nonadherence. Anxiety symptoms and patient-level perceived barriers were associated with treatment nonadherence, which was observed in 59.5% of post-cardiac transplant patients.

synapsesocial.com/papers/6a58761c2b46c88ba9ad1c6ehttps://doi.org/10.1177/15269248261469263
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