Key result
Coronary occlusion reduces ischemic LV high-frequency content, correlating with lower body surface QRS amplitude.
Why the study?
Does occlusion of the left anterior descending coronary artery alter the high-frequency content of epicardial electrograms and body surface electrocardiograms in anesthetized dogs?
Does occlusion of the left anterior descending coronary artery alter the high-frequency content of epicardial electrograms and body surface electrocardiograms in anesthetized dogs?
Coronary occlusion reduces high-frequency activity in the ischemic myocardium, which correlates with reduced amplitude in the body surface high-frequency QRS complex.
Hypothesis-generating for body surface high-frequency QRS in detecting ischemia; requires human validation before clinical use.
The very high-frequency content (150 to 250 Hz) of epicardial electrogram waveforms was studied in 19 anesthetized dogs subjected to occlusion of left anterior descending coronary artery. Computer techniques of digital averaging and digital band-pass filtering were applied. Signals were obtained from epicardial electrodes placed in the ischemic left ventricular region and on the noninjured right ventricular surface, and from the body surface electrocardiogram. All recordings were made simultaneously before, during, and after coronary occlusion and subjected to the same analysis. The waveforms obtained from the ischemic left ventricular region showed a considerable decrease in high-frequency content, while those obtained from the noninjured right ventricular surface remained unchanged. The results correlated with the appearance of a zone of reduced amplitude in the body surface high-frequency QRS complex. Therefore, this macroscopic phenomenon measured noninvasively from the body surface is explained by local reduction of high-frequency activity in the ischemic region of the myocardium.
No takes yet. Share an insight, caveat, or question.
Mor‐Avi et al. (1987) studied Coronary occlusion (n=19). Occlusion of left anterior descending coronary artery vs. Before occlusion and noninjured right ventricular surface was evaluated on High-frequency content (150 to 250 Hz) of epicardial electrogram waveforms. Coronary occlusion caused a considerable decrease in high-frequency content in the ischemic left ventricular region, correlating with reduced amplitude in the body surface high-frequency QRS complex.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: