Key result
OxLDL/β2GPI complexes and autoantibodies are linked to vascular inflammation and arterial thrombosis in SLE/APS.
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beta2-glycoprotein I (beta2GPI) is a major antigenic target for antiphospholipid antibodies. Oxidized low-density lipoprotein (oxLDL) is the principal lipoprotein found in atherosclerotic lesions, and it colocalizes with beta2GPI and immunoreactive lymphocytes. oxLDL/beta2GPI complexes appeared in the blood circulation of patients with diseases, such as systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, diabetes mellitus and chronic renal diseases. Thus, the complexes may be associated with systemic and chronic inflammation of the vasculature. IgG anti-oxLDL/beta2GPI complexes autoantibodies and their immune complexes were detected only in SLE/APS patients and in its animal model and were strongly associated with arterial thrombosis. The oxLDL/beta2GPI complexes were internalized by macrophages via IgG anti-beta2GPI antibody-mediated phagocytosis. In contrast, IgM anti-oxLDL antibodies derived from hyperlipidemic mice reduced the incidence of atherosclerosis. The distribution patterns of IgG and IgM anti-oxLDL antibodies in patients suggest the different roles of these antibodies.
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Matsuura et al. (2005) conducted a review in Atherosclerosis, systemic lupus erythematosus (SLE), and antiphospholipid syndrome (APS). Oxidized LDL/β2-glycoprotein I complexes was evaluated. Oxidized LDL/β2-glycoprotein I complexes are associated with systemic and chronic vascular inflammation, and their autoantibodies are strongly linked to arterial thrombosis in SLE/APS.
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