Key result
Qualitative point-of-care testing for cardiac markers showed an 88.9% correlation with quantitative estimation in patients with acute coronary syndrome.
Why the study?
Does qualitative point-of-care testing of cardiac biomarkers correlate with quantitative estimation in patients with acute coronary syndrome?
Observational (n=65)
No
Does qualitative point-of-care testing of cardiac biomarkers correlate with quantitative estimation in patients with acute coronary syndrome?
Qualitative point-of-care testing for cardiac biomarkers shows high correlation with quantitative methods, potentially facilitating early diagnosis of acute coronary syndrome.
POC testing agreed with quantitative markers in 89% of ACS cases; leaves open need for prospective validation before clinical adoption.
Objectives: To compare between the qualitative estimation of biochemical markers Point-of-Care testing) with the quantitative estimation of the same markers in the diagnosis of acute coronary syndrome (ACS). Design: Case-series study. Setting: This study was carried out in coronary care unit in Ibn- Sena Teaching Hospital in Mosul city from January to November, 2008. Participant: Sixty five patients with acute coronary syndrome (ACS) presented with chest pain. Main outcome measures: Three cardiac markers (Creatine kinase (CK-MB) activities (marker of necrosis), myoglobin (marker of muscle injury), and troponin I (marker of necrosis), were estimated qualitatively (near the patient= Point-of-Care testing), and quantitatively, and the results were compared. Kappa test was used for the association between the quantitative and qualitative test results. Results: The case-series study showed correlation of attributes between qualitative estimation results of troponin I, myoglobin and CK-MB and quantitative estimation results of the same parameters in (88.9%) tests. Conclusion: The early diagnosis of ACS might be facilitated by the use of qualitative point-of-care testing based on CK-MB, troponin I and myoglobin tests.
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Ahmad et al. (2011) conducted an observational in Acute coronary syndrome (ACS) (n=65). Qualitative point-of-care testing (CK-MB, myoglobin, troponin I) vs. Quantitative estimation of the same markers was evaluated on Correlation of attributes between qualitative and quantitative estimation results. Qualitative point-of-care testing for cardiac markers showed an 88.9% correlation with quantitative estimation in patients with acute coronary syndrome.
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