Key result
Among young adults experiencing an initial MI, smoking cessation within 1 year was associated with significantly lower all-cause mortality compared to persistent smoking (HR 0.30; 95% CI 0.16-0.56).
Why the study?
Despite progress in primary prevention, myocardial infarction rates continue to increase in young adults, motivating evaluation of tobacco use prevalence and the survival impact of smoking and smoking cessation.
Does smoking cessation reduce all-cause and cardiovascular mortality in young adults who experienced an initial MI?
Cohort (n=2,072)
Yes
Does smoking cessation reduce all-cause and cardiovascular mortality in young adults who experienced an initial MI?
Hazard Ratio: 0.3 (95% CI 0.16–0.56)
p-value: p=<.001
Smoking cessation within 1 year after an initial MI in young adults (≤50 years) is associated with a substantial reduction in all-cause and cardiovascular mortality.
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Supports post-MI smoking cessation counseling in young adults; extends observational data but leaves causality open to RCTs.
Biery et al. (2020) conducted a cohort in Myocardial Infarction (n=2,072). Smoking cessation vs. Persistent smoking was evaluated on All-cause mortality (HR 0.30, 95% CI 0.16-0.56, p=<.001). Among young adults experiencing an initial MI, smoking cessation within 1 year was associated with significantly lower all-cause mortality compared to persistent smoking (HR 0.30; 95% CI 0.16-0.56).
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